Biomarker Technologies highlights integrated whole transcriptome sequencing methods
Biomarker Technologies (BMKGene) has released technical resources detailing the use of integrated RNA sequencing to map gene regulation and interaction networks.
Biomarker Technologies (BMKGene) has released a new technical overview regarding whole transcriptome sequencing, a methodology designed to profile multiple RNA species simultaneously. By integrating rRNA-depleted RNA sequencing with small RNA sequencing, the approach aims to capture a more comprehensive view of the transcriptome than traditional single-method studies.
The service focuses on the combined analysis of mRNA, long non-coding RNA (lncRNA), circular RNA (circRNA), and microRNA (miRNA). According to the company, this allows researchers to examine how different RNA classes interact within competing endogenous RNA (ceRNA) networks, where circRNAs may function as regulators of miRNA activity.
This integrated perspective is intended to support the identification of gene expression patterns and the development of biological hypotheses. By connecting RNA profiles with pathway analysis, the company suggests that researchers can more effectively prioritize biomarkers for experimental validation.