BMKGene Integrates ATAC-seq and RNA-seq to Uncover Gene Regulation Mechanisms

Biomarker Technologies (BMKGene) is providing integrated ATAC-seq and RNA-seq analysis services to elucidate gene regulatory mechanisms. By combining these two methods, researchers can gain a deeper understanding of how alterations in chromatin structure affect gene expression levels across various biological conditions.

RNA-seq measures gene expression across the genome, identifying differentially expressed genes and their associated pathways. ATAC-seq, conversely, maps regions of accessible chromatin, indicating where the transcriptional machinery can bind. Integrating these datasets allows for the examination of how changes in chromatin accessibility correlate with changes in gene expression.

BMKGene offers multi-omics sequencing and bioinformatics services to support this integrated analysis. The company states this approach moves beyond identifying 'which genes changed' to exploring 'which regulatory regions changed and how these changes relate to altered gene expression.'

This integration can help identify regulatory regions directly impacting specific gene expression changes. For instance, an increase in gene expression accompanied by increased chromatin accessibility in its promoter or nearby regions provides evidence of a regulatory-expression link.