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Post-Vac Syndrome: Rare Side Effects of Coronavirus Vaccinations

Rare Post-Vac syndrome symptoms can occur after COVID-19 vaccinations. The condition particularly affects young, athletic women. Research is investigating causes and treatment methods.

24 June 2026
Post-Vac Syndrome: Rare Side Effects of Coronavirus Vaccinations

Severe, but rare, symptoms known as Post-Vac syndrome can occur following COVID-19 vaccinations. This condition, which can also manifest after other immunizations like the flu shot, has gained attention due to the high volume of people vaccinated globally within a short timeframe.

Studies indicate that the risk of severe side effects after contracting COVID-19 is substantially higher than after vaccination. The incidence of Post-Vac syndrome is estimated to be between 0.01% and 0.02% of all vaccinations. Experts suggest that those affected might have experienced similar or more severe symptoms if they had contracted the actual COVID-19 infection.

Observations suggest that Post-Vac syndrome disproportionately affects young, athletic women. According to medical professionals at the University Hospital Marburg, which hosts Germany's only Post-Vac syndrome outpatient clinic, many young patients have presented with unusual circulatory issues post-vaccination. Reported symptoms include blood pressure fluctuations, rapid heart rate, headaches, visual disturbances, fatigue, concentration difficulties, and skin changes.

The exact causes of Post-Vac syndrome are still under investigation. One theory focuses on the ACE2 molecule, crucial for blood pressure regulation and a key entry point for coronaviruses. Immune system overreactions and the formation of autoantibodies are also being explored. While treatment requires patience, methods such as immunoadsorption (a form of blood purification) are being considered and studied for efficacy.

Globally, COVID-19 vaccines remain highly effective and safe. Despite the existence of rare side effects like Post-Vac syndrome, vaccination presents a significantly lower risk than contracting COVID-19. Researchers emphasize the need for increased research funding and specialized clinics to support and advise individuals affected by or at risk of Post-Vac syndrome.

Original source: ndr.de