Research examines gene expression changes in rat model of Alzheimer's

A research project at the University of Würzburg, supported by the Alzheimer Forschung Initiative e.V. (AFI), investigated changes in gene expression within a rat model induced by streptozotocin (STZ). The study aimed to deepen the understanding of neurodegenerative mechanisms associated with Alzheimer's disease.

Led by PD Dr. Edna Grünblatt, the project ran from November 2002 to October 2004 and received funding of €68,000. The research utilized an STZ-induced rat model that mimics Alzheimer's symptoms, including deficits in learning, memory, and cognitive behavior. STZ is known to inhibit insulin receptor function, impacting glucose metabolism in the brain.

Researchers analyzed gene expression patterns in STZ-exposed rats compared to a control group using microarray technology. This method allows for the simultaneous examination of thousands of genes. The findings revealed altered expression in approximately 30 genes as a consequence of STZ treatment. These genes are involved in various cellular functions such as survival, death, differentiation, and communication.

The study confirmed the expression changes of nine genes in specific brain regions using an alternative method, offering insights into the molecular events underlying the disease. These findings may contribute to the research on Alzheimer's disease in humans and potentially lead to the development of new therapeutic strategies. The project's outcomes have been published in scientific journals.