Sage Extract Slows Aging and Extends Healthy Lifespan
New research from the University of California suggests that sage extract may slow the aging process and prolong healthy lifespan, offering new possibilities for treating age-related diseases.
Researchers at the University of California have published a study indicating that sage extract (HK) can significantly slow aging and extend healthy lifespan. The study, featured in Nature Aging, demonstrates positive effects in preventing age-related diseases.
The research team, led by Professor Andrea Alimonti, observed that when mice were administered HK extract from 20 months of age until their natural death, their average lifespan increased to 32.25 months, compared to 28 months in the control group. Furthermore, the extract improved the mice's physiological functions, including coat lustre, bone strength, grip strength, and kidney health.
To understand the mechanism of action, researchers performed RNA sequencing analysis on the mice's muscles. The results indicated that HK could down-regulate gene expression associated with aging and declining tissue function.
This discovery opens new avenues in aging research and potentially for developing novel treatments against age-related diseases such as cardiovascular and neurodegenerative conditions. Sage extract is a natural, polyphenol-rich plant extract previously utilized for its antioxidant properties.