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Study: Sleep Stages and Irregularity Linked to Disease Risk

A new study in PLOS Medicine connects deep sleep and REM sleep duration to disease risk. Short and irregular sleep patterns increase health risks.

29 September 2026
Study: Sleep Stages and Irregularity Linked to Disease Risk

New research indicates that sleep quality and consistency may be more critical to disease risk than total sleep duration alone.

The study, published in PLOS Medicine, analyzed sleep data from over 95,000 individuals and more than 1,000 health outcomes. Researchers found that greater amounts of deep sleep and REM sleep were associated with a lower risk of developing various diseases.

Specifically, higher deep sleep duration was linked to a reduced risk for 83 different diseases, while increased REM sleep was associated with a lower risk for 7 diseases. These findings highlight the distinct health implications of different sleep stages.

Conversely, sleep irregularity and wakefulness after sleep onset (WASO) were linked to elevated disease risks. Short total sleep durations (less than five hours) and inconsistent sleep patterns were associated with higher risks of illness.

The research utilized data from the UK Biobank, where participants' sleep was monitored for a week using accelerometers. Key sleep parameters such as NREM sleep duration, REM sleep duration, total sleep time, sleep irregularity, and WASO were measured. The findings suggest individuals should focus on sleep quality and regularity, not just quantity, for disease prevention.

Original source: inc.com