Ursolic Acid Supplementation in Mothers Protected Brain Axons Across Two Generations

Research led by Professor Roger Pocock at Monash University, with Dr. Wenyue Wang as the first author, has demonstrated the axon-protective effects of the natural compound ursolic acid across generations. The findings were published in the journal Nature Cell Biology.

Using the Hydrodaenoma elegans roundworm model, the study observed that maternal supplementation with ursolic acid enhanced axonal transport and reduced axonal breakage in two subsequent generations of offspring. A key mediator identified was the sphingolipid sphingosine-1-phosphate.

Ursolic acid, a triterpenoid compound found in plants, is known for various biological effects including sedative, anti-inflammatory, antibacterial, and hypoglycemic properties. It also possesses significant antioxidant functions, leading to its widespread use in pharmaceuticals and cosmetics.

Axons are crucial for maintaining neuron health, responsible for transporting essential substances like proteins and lipids. Their function deteriorates with age, contributing to brain dysfunction and neurodegeneration. This study sought to identify natural substances capable of protecting axons from age-related damage.